3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester
CAS No.:645394-77-0
Molecular Formula:C₂₃H₃₅NO₇Si
Molecular Weight:465.619
Hs Code.:

3-<i>tert</i>-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Synonyms:3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

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Chemical Property of 3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

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Technology Process of 3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

There total 5 articles about 3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₇H₁₅LiO₂Si

: 645394-76-9,159396-59-5
4-benzyloxycarbonylmethyl-2,5-dioxo-oxazolidine-3-carboxylic acid tert-butyl ester

: 645394-77-0
3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1002/anie.200352423

Reference yield:

: 51186-58-4,98482-77-0
4-benzyl Boc-D-aspartate

: 645394-77-0
3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / KHCO₃ / dimethylformamide

2: 100 percent / 4-(dimethylamino)pyridine

3: 81 percent / [RhCl(PPh₃)3] / aq. ethanol

4: 90 percent / SOCl₂; pyridine / dimethylformamide

5: 80 percent / tetrahydrofuran / -78 °C

With pyridine; dmap; thionyl chloride; tris(triphenylphosphine)rhodium(I) chloride; potassium hydrogencarbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.200352423

Reference yield:

: 645394-73-6
2-tert-butoxycarbonylamino-succinic acid 1-allyl ester 4-benzyl ester

: 645394-77-0
3-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 4-(dimethylamino)pyridine

2: 81 percent / [RhCl(PPh₃)3] / aq. ethanol

3: 90 percent / SOCl₂; pyridine / dimethylformamide

4: 80 percent / tetrahydrofuran / -78 °C

With pyridine; dmap; thionyl chloride; tris(triphenylphosphine)rhodium(I) chloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.200352423