N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

Base Information

• Chemical Name: N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester
• CAS No.: 117833-15-5
• Molecular Formula: C₅₃H₈₂N₆O₁₃
• Molecular Weight: 1011.27

Synonyms:N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

Chemical Property of N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

There total 8 articles about N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R)-tert-butyl 2-amino-3-tert-butoxybutanoate (5854-78-4) → N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-Nε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester (117833-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C / then 3 h at 20 deg C

2: hydrogen / palladium black / methanol / 5 h / 20 °C / 760 Torr

3: 85 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C / then 5 h at 20 deg C

4: hydrogen / palladium black / methanol / 5 h / 20 °C / 760 Torr

5: 0.65 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C / then 6 h at 20 deg C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-Nε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester (117833-15-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 82 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C / then 3 h at 20 deg C

2: hydrogen / palladium black / methanol / 5 h / 20 °C / 760 Torr

3: 85 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C / then 5 h at 20 deg C

4: hydrogen / palladium black / methanol / 5 h / 20 °C / 760 Torr

5: 0.65 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C / then 6 h at 20 deg C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

Nε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester (52616-66-7) → N-Z-O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-Nε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester (117833-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran / 1 h / 0 °C / then 5 h at 20 deg C

2: hydrogen / palladium black / methanol / 5 h / 20 °C / 760 Torr

3: 0.65 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C / then 6 h at 20 deg C

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

N-Z-O-tert-butyl-L-tyrosyl-L-threonine

L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

Z-Lys(Boc)-OH

(2S,3R)-tert-butyl 2-amino-3-tert-butoxybutanoate

Downstream raw materials:

O-tert-butyl-L-tyrosyl-L-threonyl-L-prolyl-N^ε-BOC-L-lysyl-O-tert-butyl-L-threonine tert-butyl ester

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