1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1268264-20-5
Molecular Formula:C₂₆H₂₄FN₅O₂
Molecular Weight:457.507
Hs Code.:

Synonyms:1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of 1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of 1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 4 articles about 1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 868171-67-9
1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1268264-39-6
C₁₄H₁₈N₄

: 1268264-20-5
1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm101340q

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1268264-20-5
1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 110 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / Reflux

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; toluene; 1: Buchwald-Hartwig coupling;
DOI:10.1021/jm101340q

Reference yield:

: 1268264-38-5
C₁₄H₁₆N₄O₂

: 1268264-20-5
1-(4-fluorophenyl)-N-(3-(4-methylpiperazin-1-yl)quinolin-5-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / ethanol; water / Reflux

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

With iron; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm101340q