N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine

Base Information

• Chemical Name: N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine
• CAS No.: 1352803-99-6
• Molecular Formula: C₂₅H₃₁FN₆O
• Molecular Weight: 450.559

Synonyms:N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine

Chemical Property of N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine

There total 5 articles about N₂-(1-(4-fluorobenzyl)piperidin-4-yl)-N₄-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.4%

N2-mesityl-6-methoxy-N4-(piperidin-4-yl)-1,3,5-triazine-2,4-diamine (1352804-12-6) → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine (1352803-99-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

6-chloro-N2-mesityl-N4-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine (1352804-07-9) → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine (1352803-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium / 4 h / 60 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: pH 8

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With sodium; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2012.02.019

Reference yield:

2,4,6-trimethylaniline (88-05-1) → N2-(1-(4-fluorobenzyl)piperidin-4-yl)-N4-mesityl-6-methoxy-1,3,5-triazine-2,4-diamine (1352803-99-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrahydrofuran / 3 h / 0 °C

2.1: sodium hydrogencarbonate / tetrahydrofuran; water; acetone / 8 h / 30 °C

3.1: sodium / 4 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

4.2: pH 8

5.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With sodium; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2012.02.019

upstream raw materials:

6-chloro-N₂-mesityl-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine

N₂-mesityl-6-methoxy-N₄-(1-Boc-piperidin-4-yl)-1,3,5-triazine-2,4-diamine

N₂-mesityl-6-methoxy-N₄-(piperidin-4-yl)-1,3,5-triazine-2,4-diamine

2,4,6-trimethylaniline

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