(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

Base Information

Chemical Name:(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine
CAS No.:277758-25-5
Molecular Formula:C₁₈H₂₇N₃O₆S
Molecular Weight:413.495
Hs Code.:

Synonyms:(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

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Chemical Property of (1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

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Technology Process of (1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

There total 6 articles about (1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 277758-52-8
(1R)-N-[α-tert-butyl N-(benzyloxycarbonyl)amino-L-γ-glutamyl]-1-(phenylsulfonylcarbamoyl)ethylamine

: 277758-25-5
(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

Guidance literature:: With hydrogen; 10percent Pd/C; In ethanol; at 20 ℃; for 3h;
DOI:10.1021/jm991119p

Reference yield:

: 98-10-2
benzenesulfonamide

: 277758-25-5
(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / 4-DMAP; EDCI / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / H₂ / 10percent Pd/C / methanol / 3.5 h / 20 °C

3: tetrahydrofuran / 4.08 h / -20 - 20 °C

4: 91 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jm991119p

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 277758-25-5
(1R)-N-(α-tert-butyl L-γ-glutamyl)-1-(phenylsulfonylcarbamoyl)ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: NMM / tetrahydrofuran / 0.17 h / -20 °C

2: tetrahydrofuran / 4.08 h / -20 - 20 °C

3: 91 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 20 °C

With 4-methyl-morpholine; hydrogen; 10percent Pd/C; In tetrahydrofuran; ethanol;
DOI:10.1021/jm991119p