N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

Base Information

Chemical Name:N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide
CAS No.:952202-56-1
Molecular Formula:C₁₉H₁₅Cl₂N₅O₃S
Molecular Weight:464.332
Hs Code.:

Synonyms:N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

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Chemical Property of N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

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Technology Process of N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

There total 4 articles about N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952202-57-2
C₂₁H₁₇Cl₂N₅O₄S

: 952202-56-1
N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

Guidance literature:: C₂₁H₁₇Cl₂N₅O₄S; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;

With water; In tetrahydrofuran;

Reference yield:

: 952202-58-3
(Z)-2-chloro-N-[3-chloro-4-(1-cyano-2-dimethylaminovinyl)phenyl]-benzenesulfonamide

: 952202-56-1
N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol / 20 - 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol;

Reference yield:

: 89277-99-6
(2-Chloro-4-nitrophenyl)acetonitrile

: 952202-56-1
N-[4-(7-amino-3-hydroxymethyl-pyrazolo[1,5-a]pyrimidin-6-yl)-3-chlorophenyl]-2-chlorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 6 h / Heating / reflux

2: hydrogen; nickel / methanol / 4 h / 20 °C

3: pyridine / 0.75 h / 20 °C

4: hydrogenchloride / ethanol / 20 - 100 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; nickel; In tetrahydrofuran; methanol; ethanol; toluene;