diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

Base Information

Chemical Name:diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate
CAS No.:852949-93-0
Molecular Formula:C₂₂H₃₂NO₅P
Molecular Weight:421.474
Hs Code.:

Synonyms:diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

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Chemical Property of diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

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Technology Process of diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

There total 4 articles about diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 852949-92-9
diethyl [4-(3'-dimethylamino-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate

: 852949-93-0
diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

Guidance literature:: diethyl [4-(3'-dimethylamino-4'-methoxymethoxybenzyl)-3,5-dimethylphenoxy]methylphosphonate; With hydrogenchloride; water; In methanol; at 20 - 100 ℃; for 0.0833333h; microwave irradiation;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 328236-44-8
2,6-dimethyl-4-(triisopropyl-silanyloxy)-benzaldehyde

: 852949-93-0
diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: triethylsilane; trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

4.2: 16 h / 20 °C

5.1: hydrogenchloride; water / methanol / 0.08 h / 20 - 100 °C / Microwave

With hydrogenchloride; triethylsilane; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 328236-43-7
(4-bromo-3,5-dimethylphenoxy)triisopropylsilane

: 852949-93-0
diethyl [4-(3'-dimethylamino-4'-hydroxybenzyl)-3,5-dimethyl-phenoxy]methylphosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; water / 4 h / -73 - -70 °C

1.2: 1.08 h / -73 - -70 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 2 h / -78 - 20 °C

3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 6 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride; water / methanol / 0.08 h / 20 - 100 °C / Microwave

With hydrogenchloride; triethylsilane; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;