3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

Base Information

Chemical Name:3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid
CAS No.:1352949-72-4
Molecular Formula:C₃₇H₄₂N₄O₅
Molecular Weight:622.764
Hs Code.:

Synonyms:3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

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Chemical Property of 3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

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Technology Process of 3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

There total 4 articles about 3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1352949-73-5
tert-butyl 1-(3-(3-(3-(benzyloxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)propyl)-1H-indole-2-carboxylate

: 1352949-72-4
3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 48h; under 2585.81 Torr;

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1352949-72-4
3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 16 h / 20 °C / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide

2.2: 16 h / 60 °C

3.1: potassium carbonate; sodium iodide / butanone / 16 h / 81 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 2585.81 Torr

With hydrogen; sodium hydride; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; toluene; butanone;

Reference yield:

: 84117-86-2
tert-butyl 1H-indole-2-carboxylate

: 1352949-72-4
3-((8-(3-(2-(tert-butoxycarbonyl)-1H-indol-1-yl)propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide

1.2: 16 h / 60 °C

2.1: potassium carbonate; sodium iodide / butanone / 16 h / 81 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 2585.81 Torr

With hydrogen; sodium hydride; potassium carbonate; sodium iodide; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; butanone;