(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

Base Information

Chemical Name:(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate
CAS No.:1354724-68-7
Molecular Formula:C₂₄H₃₄N₂O₅S₂
Molecular Weight:494.676
Hs Code.:

Synonyms:(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

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Chemical Property of (R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

Chemical Property:

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Technology Process of (R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

There total 6 articles about (R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₆N₂O₆S₂

: 1354724-68-7
(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

Guidance literature:: With silica gel; In toluene; at 20 ℃; for 0.166667h;
DOI:10.1021/ol203237r

Reference yield:

: 5309-93-3
N-thioacetylmorpholine

: 1354724-68-7
(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 1 h / -78 °C

2.1: caesium carbonate / toluene / 2 h / 20 °C

3.1: silica gel / toluene / 0.17 h / 20 °C

With silica gel; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol203237r

Reference yield:

: 1696-20-4
4-acetylmorpholine

: 1354724-68-7
(R)-methyl 5-(1-(4-methylphenylsulfonamido)heptyl)-2-morpholinothiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Lawessons reagent / tetrahydrofuran / 55 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 1 h / -78 °C

3.1: caesium carbonate / toluene / 2 h / 20 °C

4.1: silica gel / toluene / 0.17 h / 20 °C

With Lawessons reagent; silica gel; caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol203237r