(1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol

Base Information

• Chemical Name: (1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol
• CAS No.: 139965-02-9
• Molecular Formula: C₁₄H₁₈ClFO₂S
• Molecular Weight: 304.813

Synonyms:(1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol

Chemical Property of (1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol

There total 3 articles about (1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.5%

(2S,3S,RS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>hept-6-en-2-ol (139965-00-7) → (1S,2R,3S,6S,RS)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol (140148-23-8) + (1S,2S,3S,6S,RS)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol (139965-02-9)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 74 ℃; for 5h;

DOI:10.1021/jo00100a057

Reference yield:

(+)-(RS)-5-<(4-Methylphenyl)sulfinyl>pent-1-ene (118558-73-9) → (1S,2S,3S,6S,RS)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol (139965-02-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / LDA / tetrahydrofuran / 0.08 h / -65 °C

2: 19 percent / NaBH₄ / methanol; aq. NH₃ / 0.17 h / -20 °C

3: 26.5 percent / tributyltin hydride, AIBN / benzene / 5 h / 74 °C

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; lithium diisopropyl amide; In tetrahydrofuran; methanol; ammonium hydroxide; benzene;

DOI:10.1021/jo00100a057

Reference yield:

(RS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>hept-6-en-2-one → (1S,2S,3S,6S,RS)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol (139965-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 19 percent / NaBH₄ / methanol; aq. NH₃ / 0.17 h / -20 °C

2: 26.5 percent / tributyltin hydride, AIBN / benzene / 5 h / 74 °C

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; ammonium hydroxide; benzene;

DOI:10.1021/jo00100a057

upstream raw materials:

(2S,3S,R_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>hept-6-en-2-ol

(+)-(R_S)-5-<(4-Methylphenyl)sulfinyl>pent-1-ene

Downstream raw materials:

(3S,4R,5S)-3-(Benzyloxy)-4-fluoro-5-methylcyclohex-1-ene

(1R,2R,3S)-1-benzoyloxy-2-fluoro-3-methylcyclohexane

(1R,2R,3S,4R,5S)-3-(Benzyloxy)-4-fluoro-5-methylcyclohexane-1,2-diol

(1R,2R,3S,6S,R_S)-2-(Benzyloxy)-1-fluoro-6-methyl-3-<(4-methylphenyl)sulfinyl>cyclohexane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 139965-02-9 (1S,2S,3S,6S,R_S)-2-Chloro-2-fluoro-3-methyl-6-<(4-methylphenyl)sulfinyl>cyclohexan-1-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send