1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

Base Information

Chemical Name:1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid
CAS No.:1396007-73-0
Molecular Formula:C₂₉H₂₅F₃N₄O₄
Molecular Weight:550.537
Hs Code.:

Synonyms:1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

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Chemical Property of 1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

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Technology Process of 1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

There total 13 articles about 1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1396008-22-2
1-(4'-{1-methyl-5-[1-(3-trifluoromethylphenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

: 1396007-71-8
1-(4'-{1-methyl-5-[(R)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

: 1396007-73-0
1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

Guidance literature:: With carbon dioxide; In isopropyl alcohol; Resolution of racemate;

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1396007-71-8
1-(4'-{1-methyl-5-[(R)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

: 1396007-73-0
1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate; palladium diacetate; XPhos / water; toluene / 95 °C / Inert atmosphere; Sealed tube

2.1: triethylamine / dichloromethane; toluene / 0.33 h / 85 °C / Inert atmosphere

2.2: 1 h / 90 °C / Inert atmosphere; Sealed tube

3.1: chiral Whelk-O₁ (R,R)-column / Resolution of racemate

With potassium phosphate; palladium diacetate; triethylamine; XPhos; In dichloromethane; water; toluene; 1.1: |Suzuki Coupling;
DOI:10.1021/jm301022v

Reference yield:

: 1249829-92-2
4-(2-fluorophenyl)-2-methyl-2H-pyrazole-3-amine

: 1396007-71-8
1-(4'-{1-methyl-5-[(R)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

: 1396007-73-0
1-(4'-{1-methyl-5-[(S)-1-(3-trifluoromethyl-phenyl)ethoxycarbonylamino]-1H-[1,2,3]triazol-4-yl}biphenyl-4-yl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane; toluene / 0.33 h / 85 °C / Inert atmosphere

1.2: 1 h / 90 °C / Inert atmosphere; Sealed tube

2.1: chiral Whelk-O₁ (R,R)-column / Resolution of racemate

With triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm301022v