3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

Base Information

Chemical Name:3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid
CAS No.:1339036-30-4
Molecular Formula:C₂₂H₁₆F₃N₃O₂
Molecular Weight:411.383
Hs Code.:

Synonyms:3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

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Chemical Property of 3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

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Technology Process of 3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

There total 2 articles about 3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.5%

: 15793-77-8
2-hydrazinoquinoline

: 1254703-86-0
C₁₃H₁₁F₃O₄

: 1339036-30-4
3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

Guidance literature:: 2-hydrazinoquinoline; C₁₃H₁₁F₃O₄; In methanol; for 4h; Reflux;

With hydrogenchloride; sodium hydrogencarbonate; In water; ethyl acetate;

With hydrogenchloride; In water; regioselective reaction;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1339036-30-4
3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Alkaline conditions

2: methanol / 4 h / Reflux

In methanol;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield: 24.0%

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 1339036-30-4
3-{1-quinolin-2-yl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}propanoic acid

: 1339035-94-7
2-{3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-[4-(trifluoromethyl) phenyl]-1H-pyrazol-1-yl}quinoline

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009