1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole

Base Information

• Chemical Name: 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole
• CAS No.: 1337993-80-2
• Molecular Formula: C₂₃H₄₀N₃O₉P₃
• Molecular Weight: 595.507
• Mol file: 1337993-80-2.mol

Synonyms:1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole

Chemical Property of 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole

There total 4 articles about 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-butyn-1-ylidynetrisphosphonic acid hexaethyl ester (1337993-75-5) + benzyl azide (622-79-7) → 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole (1337993-80-2)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;

DOI:10.1021/jo201523w

Reference yield:

tetraethyl (3-butyn-1-ylidene)-1,1-bisphosphonate (154384-16-4) → 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole (1337993-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; benzene / 0 °C

1.2: 0.5 h / 0 °C

2.1: dihydrogen peroxide / tetrahydrofuran / 1 h / 0 °C

3.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With dihydrogen peroxide; sodium hexamethyldisilazane; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol; benzene;

DOI:10.1021/jo201523w

Reference yield:

C16H33O8P3 → 1-benzyl-4-[2,2,2-tris(diethyoxyphosphinyl)ethyl]-1H-1,2,3-triazole (1337993-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide / tetrahydrofuran / 1 h / 0 °C

2: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With dihydrogen peroxide; copper(II) sulfate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1021/jo201523w

upstream raw materials:

tetraethyl (3-butyn-1-ylidene)-1,1-bisphosphonate

3-butyn-1-ylidynetrisphosphonic acid hexaethyl ester

benzyl azide

benzyl bromide