Technology Process of 4-(4-chlorophenyl)hepta-1,2-dien-6-yn-4-ol
There total 3 articles about 4-(4-chlorophenyl)hepta-1,2-dien-6-yn-4-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
propargyl bromide;
With
magnesium; mercury dichloride;
In
diethyl ether;
at 60 ℃;
Inert atmosphere;
1-(4-chlorophenyl)buta-2,3-dien-1-one;
In
diethyl ether;
at -78 ℃;
Inert atmosphere;
DOI:10.1002/asia.201000267
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: periodic acid; pyridinium chlorochromate / acetonitrile / 0 - 20 °C
2.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
With
magnesium; periodic acid; pyridinium chlorochromate; mercury dichloride;
In
diethyl ether; acetonitrile;
DOI:10.1002/asia.201000267
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere
1.2: -23 °C / Inert atmosphere
2.1: periodic acid; pyridinium chlorochromate / acetonitrile / 0 - 20 °C
3.1: magnesium; mercury dichloride / diethyl ether / 60 °C / Inert atmosphere
3.2: -78 °C / Inert atmosphere
With
magnesium; periodic acid; pyridinium chlorochromate; mercury dichloride;
In
diethyl ether; acetonitrile;
DOI:10.1002/asia.201000267