(S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester

Base Information

• Chemical Name: (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester
• CAS No.: 1114400-52-0
• Molecular Formula: C₂₉H₃₄NO₆P
• Molecular Weight: 523.566
• Mol file: 1114400-52-0.mol

Synonyms:(S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester

Chemical Property of (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester

There total 3 articles about (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester (167905-35-3) + dimethyl methane phosphonate (756-79-6) → C29H34NO6P (1114400-86-0) + (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester (1114400-52-0)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

DOI:10.1016/j.tet.2008.11.033

Reference yield: 65.0%

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester (167905-35-3) + dimethyl methane phosphonate (756-79-6) → (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester (1114400-52-0)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

DOI:10.1055/s-0029-1217340

Reference yield:

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester (167905-35-3) + dimethyl methane phosphonate (756-79-6) → C29H34NO6P (1114400-86-0) + (S)-2-dibenzylamino-6-(dimethoxy-phosphoryl)-5-oxohexanoicacid benzyl ester (1114400-52-0) + C25H35NO8P2

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

DOI:10.1055/s-0029-1217340

upstream raw materials:

(S)-2-dibenzylaminopentanedioic acid dibenzyl ester

dimethyl methane phosphonate

Downstream raw materials:

(S,E)-2-dibenzylamino-5-oxo-6-icosenoic acid benzyl ester

C₃₅H₄₁NO₅

C₃₂H₃₆BrNO₃

C₃₆H₄₄N₂O₅