N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

Base Information

Chemical Name:N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide
CAS No.:1112178-37-6
Molecular Formula:C₁₅H₁₅N₇O₂
Molecular Weight:325.33
Hs Code.:

Synonyms:N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

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Chemical Property of N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

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Technology Process of N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

There total 6 articles about N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6-cyano-N-(3-methoxybenzyl)-2-methylpyrimidine-4-carboxamide

: 1112178-37-6
N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

Guidance literature:: With sodium azide; zinc dibromide; In water; for 16h; Reflux;
DOI:10.1021/acs.jmedchem.5b01434

Reference yield:

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 1112178-37-6
N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 1.5 h / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine / 24 h / 85 °C

3: oxalyl dichloride / dichloromethane; N,N-dimethyl acetamide / 2 h / Reflux

4: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.5 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 2 h

6: zinc dibromide; sodium azide / water / 16 h / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium azide; oxalyl dichloride; sulfuric acid; N-ethyl-N,N-diisopropylamine; zinc dibromide; In dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/acs.jmedchem.5b01434

Reference yield:

: 64532-22-5
methyl 6-hydroxy-2-methylpyrimidine-4-carboxylate

: 1112178-37-6
N-(3-methoxybenzyl)-2-methyl-6-(2H-tetrazol-5-yl)pyrimidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl acetamide / 2 h / Reflux

2: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 0.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / 2 h

4: zinc dibromide; sodium azide / water / 16 h / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; sodium azide; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; zinc dibromide; In dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/acs.jmedchem.5b01434