N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

Base Information

Chemical Name:N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide
CAS No.:1361391-89-0
Molecular Formula:C₂₄H₂₉F₂NO₄S
Molecular Weight:465.561
Hs Code.:

Synonyms:N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

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Technology Process of N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

There total 10 articles about N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.6%

: 1361391-86-7
4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexanamine

: 108-12-3
isopentanoyl chloride

: 1361391-89-0
N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield:

: 4-(benzyloxy)cyclohexyl methanesulfonate

: 1361391-89-0
N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 150 °C / Microwave irradiation

3: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 15 h / 90 °C

6: hydrogen / palladium on activated charcoal / methanol / 1.5 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With sodium azide; hydrogen; potassium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1361391-80-1
4-(4-(benzyloxy)cyclohexyloxy)-3,5-difluoro-4'-(methylsulfonyl)biphenyl

: 1361391-89-0
N-(4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl)-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 15 h / 90 °C

4: hydrogen / palladium on activated charcoal / methanol / 1.5 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

With sodium azide; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;