tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Base Information

Chemical Name:tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate
CAS No.:959433-88-6
Molecular Formula:C₃₃H₄₄N₄O₆
Molecular Weight:592.736
Hs Code.:

tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Synonyms:tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Property of tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

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Technology Process of tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

There total 6 articles about tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 959433-87-5
(S)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide hydrochloride

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: 959433-88-6
tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: (S)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide hydrochloride; N-(tert-butoxycarbonyl)-N-methyl-L-alanine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; Inert atmosphere; Cooling with ice;

With N-ethyl-N,N-diisopropylamine; at 20 ℃; Cooling with ice;

Reference yield:

: 934963-44-7
(S)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

: 959433-88-6
tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C / Inert atmosphere; Cooling with ice

1.2: 20 °C / Cooling with ice

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C / Inert atmosphere; Cooling with ice

3.2: 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;

Reference yield:

: 959433-86-4
tert-butyl (S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylcarbamate

: 959433-88-6
tert-butyl (S)-1-((S)-3-(4-hydroxyphenyl)-1-oxo-1-((S)-2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)propan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.5 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C / Inert atmosphere; Cooling with ice

2.2: 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane;