(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

Base Information

Chemical Name:(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride
CAS No.:128777-40-2
Molecular Formula:C₁₈H₃₂F₂INO₂*ClH
Molecular Weight:495.82
Hs Code.:

Synonyms:(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

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Chemical Property of (2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

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Technology Process of (2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

There total 1 articles about (2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 121596-23-4,128707-37-9
(2R,3R,5R)-2-Cyclohexylmethyl-6-ethoxy-4,4-difluoro-3-iodo-5-isobutyl-2,3,4,5-tetrahydro-pyridine

: 128777-40-2
(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1021/ja00173a066

Reference yield: 87.0%

: 128777-40-2
(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

: 501-53-1,94274-21-2
benzyl chloroformate

: 121584-80-3
(2R,4R,5R)-5-Benzyloxycarbonylamino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/ja00173a066

Reference yield:

: 128777-40-2
(2R,4R,5R)-5-Amino-6-cyclohexyl-3,3-difluoro-4-iodo-2-isobutyl-hexanoic acid ethyl ester; hydrochloride

: 121584-81-4,128707-38-0
(2R,4S,5R)-5-Benzyloxycarbonylamino-6-cyclohexyl-3,3-difluoro-4-hydroxy-2-isobutyl-hexanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / aq. NaHCO₃ / tetrahydrofuran / 0 °C

2: 73 percent / buffered peroxytrifluoroacetic acid / CH₂Cl₂ / 0 °C

With buffered peroxytrifluoroacetic acid; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00173a066