(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

Base Information

Chemical Name:(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine
CAS No.:906097-72-1
Molecular Formula:C₂₃H₃₉NO₃SSi
Molecular Weight:437.719
Hs Code.:

Synonyms:(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

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Technology Process of (3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

There total 1 articles about (3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 906097-71-0
(2S,3R,6S,E)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-methyl-6-(5-(phenylsulfonyl)pent-4-enyl)piperidine-1-carboxylate

: 906097-72-1
(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

Guidance literature:: (2S,3R,6S,E)-tert-butyl 3-(tert-butyldimethylsilyloxy)-2-methyl-6-(5-(phenylsulfonyl)pent-4-enyl)piperidine-1-carboxylate; With aluminium trichloride; In dichloromethane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ol060960b

Reference yield:

: 906097-72-1
(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

: 18829-55-5
(E)-2-Heptenal

: (E)-1-Benzenesulfonyl-1-[(4S,6S,7R,9aS)-7-(tert-butyl-dimethyl-silanyloxy)-6-methyl-octahydro-quinolizin-4-yl]-oct-3-en-2-ol

Guidance literature:: (3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

(E)-2-Heptenal; In tetrahydrofuran; hexane; at -50 ℃; for 1h;
DOI:10.1021/ol060960b

Reference yield:

: 906097-72-1
(3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine

: 18829-56-6
(E)-2-Nonenal

: (E)-1-Benzenesulfonyl-1-[(4S,6S,7R,9aS)-7-(tert-butyl-dimethyl-silanyloxy)-6-methyl-octahydro-quinolizin-4-yl]-dec-3-en-2-ol

Guidance literature:: (3R,4S,6S,9aS)-3-(tert-butyldimethylsilyloxy)-4-methyl-6-(phenylsulfonylmethyl)-octahydro-quinolizine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

(E)-2-Nonenal; In tetrahydrofuran; hexane; at -50 ℃; for 1h;
DOI:10.1021/ol060960b