(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Base Information

Chemical Name:(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester
CAS No.:162362-12-1
Molecular Formula:C₂₄H₃₂O₅
Molecular Weight:400.515
Hs Code.:

Synonyms:(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

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Chemical Property of (1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

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Technology Process of (1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

There total 4 articles about (1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 162361-98-0
(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

: 162362-12-1
(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; Ambient temperature;
DOI:10.1021/ja00093a013

Reference yield:

: 98919-68-7
(1R,2S)-trans-2-phenylcyclohexanol

: 162362-12-1
(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / Heating

2: conc. H₂SO₄ / CH₂Cl₂ / Ambient temperature

3: 47 percent / Et₂AlCl / CH₂Cl₂ / 13 h / -20 °C

4: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / Ambient temperature

With sulfuric acid; hydrogen; diethylaluminium chloride; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ja00093a013

Reference yield:

: (Z)-But-2-enedioic acid mono-((1R,2S)-2-phenyl-cyclohexyl) ester

: 162362-12-1
(1R,2R,3S,4S)-7-Oxa-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-((1R,2S)-2-phenyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: conc. H₂SO₄ / CH₂Cl₂ / Ambient temperature

2: 47 percent / Et₂AlCl / CH₂Cl₂ / 13 h / -20 °C

3: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 2 h / Ambient temperature

With sulfuric acid; hydrogen; diethylaluminium chloride; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00093a013