(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

Base Information

Chemical Name:(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide
CAS No.:124942-85-4
Molecular Formula:C₂₄H₃₇N₃O₃
Molecular Weight:415.576
Hs Code.:

Synonyms:(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

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Chemical Property of (1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

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Technology Process of (1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

There total 1 articles about (1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67198-53-2
trans-N-methyl-2-(1-pyrrolidinyl)-cyclohexanamine

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 124942-85-4
(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; In dichloromethane; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00166a014

Reference yield: 87.0%

: 124942-85-4
(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

: 124942-81-0
(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-(S)-2-amino-2-phenylacetamide

Guidance literature:: With hydrogenchloride; at 60 ℃; for 0.166667h;
DOI:10.1021/jm00166a014

Reference yield:

: 124942-85-4
(1S,2S)-trans-N-methyl-N-<2-(1-pyrrolidinyl)cyclohexyl>-N-t-Boc-(S)-2-amino-2-phenylacetamide

: 124942-78-5
(S)-2-Isothiocyanato-N-methyl-2-phenyl-N-((1S,2S)-2-pyrrolidin-1-yl-cyclohexyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 3 M HCl / 0.17 h / 60 °C

2: aq. NaHCO₃ / CHCl₃ / 0.33 h / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; In chloroform;
DOI:10.1021/jm00166a014