6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

Base Information

Chemical Name:6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine
CAS No.:1265221-93-9
Molecular Formula:C₁₇H₁₈ClF₃N₄OSi
Molecular Weight:414.89
Hs Code.:

Synonyms:6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

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Chemical Property of 6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

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Technology Process of 6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

There total 2 articles about 6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 401-81-0
m-trifluoromethylphenyl iodide

: 1265221-82-6
6-chloro-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purine

: 1265221-93-9
6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

Guidance literature:: 6-chloro-9-(methoxymethyl)-2-(trimethylsilyl)-9H-purine; With zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; at 25 ℃; for 0.25h; Inert atmosphere;

m-trifluoromethylphenyl iodide; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 45 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol103057k

Reference yield:

: 6504-64-9
6-chloro-9-(methoxymethyl)-9H-purine

: 1265221-93-9
6-chloro-9-(methoxymethyl)-8-(3-(trifluoromethyl)phenyl)-2-(trimethylsilyl)-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 °C / Inert atmosphere

2.1: zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex / tetrahydrofuran / 0.25 h / 25 °C / Inert atmosphere

2.2: 14 h / 45 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex; In tetrahydrofuran; hexane; 2.2: Negishi coupling reaction;
DOI:10.1021/ol103057k