N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester

Base Information

• Chemical Name: N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester
• CAS No.: 174537-25-8
• Molecular Formula: C₂₂H₁₈IN₃O₇
• Molecular Weight: 563.305
• Mol file: 174537-25-8.mol

Synonyms:N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester

Chemical Property of N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester

There total 4 articles about N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-iodo-benzaldehyde (60032-63-5) → N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester (174537-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 0.5 h / 50 °C

2: NaBH₃CN / tetrahydrofuran; acetic acid / Ambient temperature

3: 0.5M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; chloroform; acetic acid; toluene;

DOI:10.1016/0223-5234(96)88312-7

Reference yield:

N-benzyloxycarbonyl-hydrazine (5331-43-1) → N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester (174537-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 0.5 h / 50 °C

2: NaBH₃CN / tetrahydrofuran; acetic acid / Ambient temperature

3: 0.5M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; chloroform; acetic acid; toluene;

DOI:10.1016/0223-5234(96)88312-7

Reference yield:

N'-[1-(4-Hydroxy-3-iodo-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid benzyl ester → N-benzyloxycarbonyl-3-iodo-α-azatyrosyl-p-nitrophenylester (174537-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₃CN / tetrahydrofuran; acetic acid / Ambient temperature

2: 0.5M aq. NaHCO₃ / CHCl₃ / 0.5 h / Ambient temperature

With sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; chloroform; acetic acid;

DOI:10.1016/0223-5234(96)88312-7

upstream raw materials:

4-Nitrophenyl chloroformate

N'-(4-Hydroxy-3-iodo-benzyl)-hydrazinecarboxylic acid benzyl ester

N-benzyloxycarbonyl-hydrazine

4-hydroxy-3-iodo-benzaldehyde

Downstream raw materials:

C₂₁H₂₆IN₃O₆