[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

Base Information

Chemical Name:[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine
CAS No.:1240608-27-8
Molecular Formula:C₂₄H₁₉F₂N₅
Molecular Weight:415.445
Hs Code.:

Synonyms:[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

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Chemical Property of [3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

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Technology Process of [3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

There total 7 articles about [3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 252340-70-8
5-Amino-2-(4-methyl-imidazol-1-yl)fluorobenzene

: 1239719-55-1
4-bromo-2-(4-fluorophenyl)-1-methyl-1H-benzimidazole

: 1240608-27-8
[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In tert-butyl alcohol; at 110 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm201710f

Reference yield:

: 252337-29-4
3-fluoro-4-(4-methyl-imidazol-1-yl)nitrobenzene

: 1240608-27-8
[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: thiophene; 10% Pd/C; hydrogen / methanol; di-isopropyl ether / 25 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10% Pd/C; hydrogen; caesium carbonate; XPhos; In methanol; di-isopropyl ether; tert-butyl alcohol;
DOI:10.1021/jm201710f

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1240608-27-8
[3-fluoro-4-(4-methylimidazol-1-yl)phenyl]-[2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 4 h / 125 °C

2: thiophene; 10% Pd/C; hydrogen / methanol; di-isopropyl ether / 25 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos / tert-butyl alcohol / 20 h / 110 °C / Inert atmosphere

With thiophene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10% Pd/C; hydrogen; caesium carbonate; XPhos; In methanol; di-isopropyl ether; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm201710f