N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

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Chemical Name:N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide
CAS No.:1353576-39-2
Molecular Formula:C₁₉H₂₀ClFN₄O₄S₃
Molecular Weight:519.042
Hs Code.:

Synonyms:N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

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Chemical Property of N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

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Technology Process of N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

There total 8 articles about N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353576-38-1
N-(3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

: 1353576-39-2
N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

Guidance literature:: N-(3-(2-tert-butyl-5-(2-(methylthio)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; pH=7 - 8;

Reference yield:

: 179897-90-6
1,3-dibromo-2-chloro-5-fluoro-benzene

: 1353576-39-2
N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 18 h / 70 °C / Inert atmosphere

2.1: triethylamine / [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride / 18 h / 100 °C / 3620.13 Torr / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

3.2: 1 h / 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 1 h / -5 - 5 °C

5.1: ISOPROPYLAMIDE / 4 h / 20 - 80 °C / Inert atmosphere

6.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

6.2: pH 8

7.1: pyridine / 18 h / 20 °C

7.2: 2 h / 65 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

8.2: pH 7 - 8

With pyridine; hydrogenchloride; N-Bromosuccinimide; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ISOPROPYLAMIDE; water;

Reference yield:

: 1353575-26-4
N-(3-bromo-2-chloro-5-fluorphenyl)pivalamide

: 1353576-39-2
N-(3-(2-tert-butyl-5-(2-(methylsulfonyl)pyrimidin-4-yl)thiazol-4-yl)-2-chloro-5-fluorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride / 18 h / 100 °C / 3620.13 Torr / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C

2.2: 1 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 1 h / -5 - 5 °C

4.1: ISOPROPYLAMIDE / 4 h / 20 - 80 °C / Inert atmosphere

5.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

5.2: pH 8

6.1: pyridine / 18 h / 20 °C

6.2: 2 h / 65 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

7.2: pH 7 - 8

With pyridine; hydrogenchloride; N-Bromosuccinimide; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; [(R)-(+)-1,1‘-binaphthalene-2,2’-diylbis(diphenylphosphane)]palladium(II)chloride; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water;