N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Base Information

• Chemical Name: N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine
• CAS No.: 160375-49-5
• Molecular Formula: C₄₂H₄₉N₉O₇
• Molecular Weight: 791.907

Synonyms:N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

Chemical Property of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

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Technology Process of N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

There total 1 articles about N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

erythro-N?-Triphenylmethyl-β-hydroxy-L-histidinmethylester (142582-33-0) + 3-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)-3(S)-<(2-(((tert-butyloxy)carbonyl)amino)ethyl)amino>propionamide (157916-91-1) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-49-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 23 ℃; for 48h;

Reference yield: 100.0%

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-49-5) → Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-50-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; at -10 ℃; for 2h;

Reference yield:

Nα-((tert-butyloxy)carbonyl)-Nβ-<1-amino-3(S)-(4-amino-6-(amido-Nim-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl methyl ester)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine (160375-49-5) → Nα-((tert-butyloxy)carbonyl)-Nim-(triphenylmethyl)descarboxamidodeglycobleomycin A2

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 1 N aq. LiOH / tetrahydrofuran; methanol / 2 h / -10 °C

2: 52 percent / HOAt, NaHCO₃, DCC / dimethylformamide / 96 h / 23 °C

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

erythro-N^?-Triphenylmethyl-β-hydroxy-L-histidinmethylester

3-(6-amino-4-carboxy-5-methylpyrimidin-2-yl)-3(S)-<(2-(((tert-butyloxy)carbonyl)amino)ethyl)amino>propionamide

Downstream raw materials:

N^α-((tert-butyloxy)carbonyl)-N^β-<1-amino-3(S)-(4-amino-6-(amido-N^im-(triphenylmethyl)-erythro-β-hydroxy-L-histidyl)-5-methylpyrimidin-2-yl)propion-3-yl>-2-amino-1-ethylamine

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