Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI)

Base Information

• Chemical Name: Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI)
• CAS No.: 398137-19-4
• Molecular Formula: C9H18 N2 O
• Molecular Weight: 170.25
• Hs Code.: 2934999090
• Mol file: 398137-19-4.mol

Synonyms:1-(Tetrahydro-2H-pyran-4-yl)piperazine;1-(Tetrahydropyran-4-yl)piperazine

Chemical Property of Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI)

Chemical Property:

• Boiling Point: 270.1±35.0 °C(Predicted)
• PKA: 9.13±0.10(Predicted)
• PSA: 24.50000
• Density: 1.033±0.06 g/cm3(Predicted)
• LogP: 0.33730
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

1-(Oxan-4-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI)

There total 5 articles about Piperazine,1-(tetrahydro-2H-pyran-4-yl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 1-(tetrahydro-2H-pyran-4-yl)piperazine (398137-19-4)

Guidance literature:

Reference yield:

1-benzyl-4-(tetrahydro-2H-pyran-4-yl)piperazine (1033594-04-5) → 1-(tetrahydro-2H-pyran-4-yl)piperazine (398137-19-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h;

Reference yield:

4-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylic acid tert-butyl ester (706759-32-2) → 1-(tetrahydro-2H-pyran-4-yl)piperazine (398137-19-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm031028z

upstream raw materials:

4-(tetrahydro-2H-pyran-4-yl)piperazine-1-carboxylic acid tert-butyl ester

Tetrahydro-4H-pyran-4-one

4-ethoxycarbonylpiperazine

1-benzyl-4-(tetrahydro-2H-pyran-4-yl)piperazine

Downstream raw materials:

4-(tetrahydro-pyran-4-yl)-piperazine-1-carbothioic acid amide

4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

5-amino-2-[4-(3,4,5,6-tetrahydro-2H-pyran-1-yl)piperazin-1-yl]benzonitrile

4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidine-1-carboxylic acid (R)-1-(4-hydroxy-3,5-dimethyl-benzyl)-2-oxo-2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-ethyl ester

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