N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

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Chemical Name:N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide
CAS No.:1005181-09-8
Molecular Formula:C₂₆H₂₂N₂O₄
Molecular Weight:426.472
Hs Code.:

Synonyms:N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

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Chemical Property of N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

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Technology Process of N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 3 articles about N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1233345-51-1
ethyl 2-[3-(4-benzoylphenylamino)-3-oxopropanamido]-4-phenylbutanoate

: 1005181-09-8
N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: ethyl 2-[3-(4-benzoylphenylamino)-3-oxopropanamido]-4-phenylbutanoate; With sodium ethanolate; In ethanol; at 20 ℃; for 24h;

With hydrogenchloride; In water; pH=< 5;
DOI:10.1021/bi100523c

Reference yield:

: 1233345-50-0
methyl 3-(4-benzoylphenylamino)-3-oxopropanoate

: 1005181-09-8
N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 16 h / 20 °C

1.2: pH < 5 / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium ethanolate / ethanol / 24 h / 20 °C

3.2: pH < 5

With sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/bi100523c

Reference yield:

: 1137-41-3,444317-48-0
(4-aminophenyl)(phenyl)methanone

: 1005181-09-8
N-(4-benzoylphenyl)-4-hydroxy-2-oxo-5-(2-phenylethyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran; dichloromethane / 18 h / 0 - 20 °C

2.1: sodium hydroxide / methanol; water / 16 h / 20 °C

2.2: pH < 5 / Cooling with ice

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: sodium ethanolate / ethanol / 24 h / 20 °C

4.2: pH < 5

With sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/bi100523c