3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

Base Information

Chemical Name:3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester
CAS No.:192774-18-8
Molecular Formula:C₄₀H₄₅N₃O₆S
Molecular Weight:695.88
Hs Code.:

Synonyms:3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

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Chemical Property of 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

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Technology Process of 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

There total 10 articles about 3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 192773-15-2
2-(3,5-dimethylphenyl)-3-{2-[4-(4-methanesulfonylamino-phenyl)butylamino]ethyl}-1H-indole-5-carboxylic acid ethyl ester

: 192774-18-8
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at -78 ℃;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 192774-18-8
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: BOP; Et₃N / CH₂Cl₂

2: H₂ / Pd(OH)2/C / ethanol

3: pyridine

4: LiAlH₄ / tetrahydrofuran / 0 °C

5: MgSO₄ / CDCl₃ / -10 - -5 °C

6: NaBH₄ / methanol / -5 °C

7: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; magnesium sulfate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8

Reference yield:

: 192774-14-4
4-(4-nitrophenyl)butyric acid, N-methoxy-N-methylamide

: 192774-18-8
3-(2-{benzyloxycarbonyl-[4-(4-methanesulfonylamino-phenyl)butyl]amino}ethyl)-2-(3,5-dimethylphenyl)-1H-indole-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Pd(OH)2/C / ethanol

2: pyridine

3: LiAlH₄ / tetrahydrofuran / 0 °C

4: MgSO₄ / CDCl₃ / -10 - -5 °C

5: NaBH₄ / methanol / -5 °C

6: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; magnesium sulfate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; chloroform-d1; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(01)00274-8