4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Base Information

Chemical Name:4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
CAS No.:1035345-83-5
Molecular Formula:C₂₁H₂₇N₃O₄
Molecular Weight:385.463
Hs Code.:

Synonyms:4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

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Chemical Property of 4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

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Technology Process of 4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

There total 1 articles about 4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1035345-80-2
4-cyano-4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1035345-83-5
4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Guidance literature:: 4-cyano-4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester; With sulfuric acid; water; at 100 ℃;

di-tert-butyl dicarbonate; With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 5h; pH=13;

With hydrogenchloride; water; In tetrahydrofuran; pH=5;

Reference yield: 61.0%

: 1035345-83-5
4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1035345-84-6
{4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidin-4-yl}-methanol

Guidance literature:: 4-[3-(1-methyl-1H-pyrazol-4-yl)-phenyl]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 ℃; for 3.5h;

With sodium hydroxide; water; In tetrahydrofuran;

trifluoroacetic acid; In dichloromethane; for 0.5h;