14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

Base Information

Chemical Name:14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin
CAS No.:89164-83-0
Molecular Formula:C₅₁H₅₂N₂O₁₂
Molecular Weight:884.98
Hs Code.:

Synonyms:14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

Chemical Property:

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Technology Process of 14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

There total 3 articles about 14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 89164-82-9
14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)doxorubicin

: 89164-83-0
14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

Guidance literature:: With ammonia; In methanol; dichloromethane; 1.) 0 deg C, 1 h, 2.) 3 deg C, 27 h;
DOI:10.1021/jm00371a014

Reference yield:

: 89196-04-3
3'-deamino-3'-(4-morpholinyl)doxorubicin hydrochloride

: 89164-83-0
14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / 48 h / Ambient temperature

2: 58 percent / NH₃ / CH₂Cl₂; methanol / 1.) 0 deg C, 1 h, 2.) 3 deg C, 27 h

With pyridine; ammonia; In methanol; dichloromethane;
DOI:10.1021/jm00371a014

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 89164-83-0
14-O-(p-anisyldiphenylmethyl)-3'-deamino-3'-(4-morpholinyl)-5-iminodoxorubicin

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridine / 48 h / Ambient temperature

2: 58 percent / NH₃ / CH₂Cl₂; methanol / 1.) 0 deg C, 1 h, 2.) 3 deg C, 27 h

With pyridine; ammonia; In methanol; dichloromethane;
DOI:10.1021/jm00371a014