[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

Base Information

Chemical Name:[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester
CAS No.:872426-24-9
Molecular Formula:C₁₆H₂₄NO₆PS
Molecular Weight:389.409
Hs Code.:

[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid <i>S</i>-(2-acetylamino-ethyl) ester <i>O</i>-ethyl ester

Synonyms:[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

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Chemical Property of [2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

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Technology Process of [2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

There total 4 articles about [2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 872426-19-2
{2-[4-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethoxy-phenyl]-vinyl}-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

: 872426-24-9
[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

Guidance literature:: With triethylamine hydrofluoride; In tetrahydrofuran; at -25 ℃;
DOI:10.1021/jm050454c

Reference yield:

: 872426-16-9
{2-[4-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethoxy-phenyl]-vinyl}-phosphonic acid diethyl ester

: 872426-24-9
[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / oxalyl chloride / CH₂Cl₂ / 20 h / 20 °C

2: 59 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

3: 49 percent / Et₃N*HF / tetrahydrofuran / -25 °C

With oxalyl dichloride; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050454c

Reference yield:

: 321558-45-6
diethyl (E)-2-(4-hydroxy-3,5-dimethoxyphenyl)vinylphosphonate

: 872426-24-9
[2-(4-hydroxy-3,5-dimethoxy-phenyl)-vinyl]-phosphonothioic acid S-(2-acetylamino-ethyl) ester O-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / N,N-dimethylaminopyridine; imidazole / dimethylformamide / 16 h / 20 °C

2: 100 percent / oxalyl chloride / CH₂Cl₂ / 20 h / 20 °C

3: 59 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

4: 49 percent / Et₃N*HF / tetrahydrofuran / -25 °C

With 1H-imidazole; dmap; oxalyl dichloride; triethylamine hydrofluoride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050454c