2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

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Chemical Name:2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate
CAS No.:1195768-49-0
Molecular Formula:C₂₁H₂₀ClFN₄O₂S
Molecular Weight:446.933
Hs Code.:

Synonyms:2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

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Chemical Property of 2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

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Technology Process of 2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

There total 3 articles about 2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

: 630-22-8
2,2-dimethylpropanethioamide

: 1195768-48-9
2-propen-1-yl {5-[(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}carbamate

: 1195768-49-0
2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

Guidance literature:: 2-propen-1-yl {5-[(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}carbamate; With N-Bromosuccinimide; In N,N-dimethyl acetamide; at 20 ℃; for 1h;

2,2-dimethylpropanethioamide; In N,N-dimethyl acetamide; at 0 - 80 ℃;

Reference yield:

: 1195768-47-8
methyl 4-fluoro-3-{[(2-propen-1-yloxy)carbonyl]amino}benzoate

: 1195768-49-0
2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

1.2: 1.33 h / 0 - 20 °C

2.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 1 h / 20 °C

2.2: 0 - 80 °C

With N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 369-26-6
methyl 3-amino-4-fluorobenzoate

: 1195768-49-0
2-propen-1-yl {5-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -10 - 0 °C

2.2: 1.33 h / 0 - 20 °C

3.1: N-Bromosuccinimide / N,N-dimethyl acetamide / 1 h / 20 °C

3.2: 0 - 80 °C

With N-Bromosuccinimide; sodium hydrogencarbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl acetamide; water;