Technology Process of 4-((2S,3R,6S)-6-(2-((tert-butyl)diphenylsilyloxy)ethyl)-3-methyl-1-tosylpiperidin-2-yl)butan-1-ol
There total 12 articles about 4-((2S,3R,6S)-6-(2-((tert-butyl)diphenylsilyloxy)ethyl)-3-methyl-1-tosylpiperidin-2-yl)butan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1039/c1cc13048j
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 0 - 20 °C
2.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C
3.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C
3.2: -78 - 20 °C
4.1: trifluoroacetic acid / acetone / 20 °C
5.1: diethylzinc / hexane; toluene / 60 h / 0 °C
6.1: N-iodo-succinimide / 3 h / 20 °C / Inert atmosphere
7.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Reflux
8.1: boron trifluoride diethyl etherate / dichloromethane / -85 °C
9.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 750.08 Torr
10.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
With
1H-imidazole; N-iodo-succinimide; lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; 2,2'-azobis(isobutyronitrile); tributylphosphine; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; diethylzinc; tri-n-butyl-tin hydride; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; 2,3-dimercapto-succinic acid; hexane; dichloromethane; ethyl acetate; acetone; toluene;
1.1: Mitsunobu reaction;
DOI:10.1039/c1cc13048j
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 1H-imidazole / tetrahydrofuran / 0 - 20 °C
2.1: copper(I) bromide dimethylsulfide complex / 2,3-dimercapto-succinic acid / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: trifluoroacetic acid / acetone / 20 °C
4.1: diethylzinc / hexane; toluene / 60 h / 0 °C
5.1: N-iodo-succinimide / 3 h / 20 °C / Inert atmosphere
6.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / Reflux
7.1: boron trifluoride diethyl etherate / dichloromethane / -85 °C
8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h / 20 °C / 750.08 Torr
9.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
With
1H-imidazole; N-iodo-succinimide; lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; diethylzinc; tri-n-butyl-tin hydride; trifluoroacetic acid;
In
tetrahydrofuran; 2,3-dimercapto-succinic acid; hexane; dichloromethane; ethyl acetate; acetone; toluene;
DOI:10.1039/c1cc13048j
