1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide

Base Information

• Chemical Name: 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide
• CAS No.: 85250-63-1
• Molecular Formula: C₁₅H₁₉N₃O₃
• Molecular Weight: 289.334
• Mol file: 85250-63-1.mol

Synonyms:1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide

Chemical Property of 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide

There total 2 articles about 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

1-(methoxycarbonyl)-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxamide (85250-62-0) + benzylamine (100-46-9) → 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide (85250-63-1)

Guidance literature:

With molecular sieve; In toluene; for 100h; Heating;

DOI:10.1021/jm00360a020

Reference yield:

4-Hydroxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester (68710-81-6) → 1-(methoxycarbonyl)-4-(benzylamino)-1,2,5,6-tetrahydropyridine-3-carboxamide (85250-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / aq. NH₃ / 120 h

2: 49 percent / molecular sieve / toluene / 100 h / Heating

With ammonium hydroxide; molecular sieve; In toluene;

DOI:10.1021/jm00360a020

upstream raw materials:

1-(methoxycarbonyl)-4-hydroxy-1,2,5,6-tetrahydropyridine-3-carboxamide

benzylamine

4-Hydroxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 3-ethyl ester 1-methyl ester