4,4,4-TRIFLUOROBUTA-1,2-DIENE

Base Information

• Chemical Name: 4,4,4-TRIFLUOROBUTA-1,2-DIENE
• CAS No.: 406-40-6
• Molecular Formula: C4H3 F3
• Molecular Weight: 108.063
• Mol file: 406-40-6.mol

Synonyms:(Trifluoromethyl)allene

Chemical Property of 4,4,4-TRIFLUOROBUTA-1,2-DIENE

Chemical Property:

• Vapor Pressure: 382mmHg at 25°C
• Refractive Index: 1.319
• Boiling Point: 44°C at 760 mmHg
• PSA: 0.00000
• Density: 1.032g/cm³
• LogP: 1.88980

Purity/Quality:

99%min ^*data from raw suppliers

4,4,4-TRIFLUOROBUTA-1,2-DIENE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-TRIFLUOROBUTA-1,2-DIENE

There total 6 articles about 4,4,4-TRIFLUOROBUTA-1,2-DIENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

propargyl p-toluenesulfonate (6165-76-0) + trifluoromethylcopper(I) (77152-08-0) → 4,4,4-trifluorobuta-1,2-diene (406-40-6)

Guidance literature:

In N,N-dimethyl-formamide; 0 deg C to RT;

DOI:10.1016/S0040-4039(00)97448-3

Reference yield: 43.0%

(trifluoromethyl)cadmiumbromide (97571-11-4) + propargyl bromide (106-96-7) → 4,4,4-trifluorobuta-1,2-diene (406-40-6)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide; -78 deg C -> RT;

Reference yield:

propargyl 2-chloro-2,2-difluoroacetate (118373-19-6) → 4,4,4-trifluorobuta-1,2-diene (406-40-6) + propargyl fluoride (2805-22-3)

Guidance literature:

With potassium fluoride; copper(l) iodide; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

DOI:10.1039/P19940000725

upstream raw materials:

4,4,4-trifluoro-2-iodo-but-1-ene

propargyl p-toluenesulfonate

trifluoromethylcopper(I)

propargyl 2-chloro-2,2-difluoroacetate

Refernces

• 1、 Duan, Jian-Xing,Chen, Quing-Yun. "Novel Synthesis of 2,2,2-Trifluoroethyl Compounds from Homoallylic Alcohols: A Copper(I) Iodide-initiated Trifluoromethyl-Dehydroxylation Process". . p. 725 - 730. Retrieved 2007/10/02.
• 2、 Burton, Donald J.,Hartgraves, Greg A.,Hsu, Jeffrey. "A facile, general route to perfluoroalkyl allenes". . p. 3699 - 3702. Retrieved 2007/10/02.