(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

Base Information

Chemical Name:(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one
CAS No.:145655-08-9
Molecular Formula:C₃₁H₃₅NO₄
Molecular Weight:485.623
Hs Code.:

(3R,5S,1'S)-3-Benzyl-5-<1'-<N-(tert-butoxycarbonyl)benzylamino>-2'-phenylethyl>dihydrofuran-2(3H)-one

Synonyms:(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

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Chemical Property of (3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

Chemical Property:

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Technology Process of (3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

There total 18 articles about (3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 145655-07-8
(5S,1'S)-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

: 620-05-3
iodomethylbenzene

: 145655-08-9
(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; 1.) -78 deg C, 20 min, 2.) -78 deg C, 30 min;
DOI:10.1021/jo00129a037

Reference yield:

: 145655-04-5
(E)-(S)-5-(Benzyl-tert-butoxycarbonyl-amino)-4-oxo-6-phenyl-hex-2-enoic acid methyl ester

: 145655-08-9
(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / Pd/BaSO₄ / methanol / 4 h / 760 Torr / Ambient temperature

2: NaBH₄ / methanol / 2 h / -50 °C

With sodium tetrahydroborate; hydrogen; Pd-BaSO₄; In methanol;
DOI:10.1016/S0040-4039(00)60888-2

Reference yield:

: 145655-03-4
(E)-(4S,5S)-5-(Benzyl-tert-butoxycarbonyl-amino)-4-hydroxy-6-phenyl-hex-2-enoic acid methyl ester

: 145655-08-9
(3R,5S,1'S)-3-Benzyl-5-<1'--2'-phenylethyl>dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Ac₂O/DMSO / 18 h / Ambient temperature

2: 88 percent / H₂ / Pd/BaSO₄ / methanol / 4 h / 760 Torr / Ambient temperature

3: NaBH₄ / methanol / 2 h / -50 °C

With sodium tetrahydroborate; hydrogen; acetic anhydride; dimethyl sulfoxide; Pd-BaSO₄; In methanol;
DOI:10.1016/S0040-4039(00)60888-2