3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel
CAS No.:926306-91-4
Molecular Formula:C₄₃H₅₅F₂NO₁₆
Molecular Weight:879.904
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

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Chemical Property of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

Chemical Property:

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Technology Process of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

There total 10 articles about 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₈H₈₉F₂NO₁₆Si₂

: 926306-91-4
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 194720-19-9
7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III

: 926306-91-4
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 7 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / -10 °C

2: diisopropyl-carbodiimide; dmap / dichloromethane

3: pyridine; hydrogen fluoride / acetonitrile

4: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran

6: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

7: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; hydrogen fluoride; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium hexamethyldisilazane; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 259522-65-1
7,10,13-tri(triethylsilyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-deacetylbaccatin III

: 926306-91-4
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-methoxybenzoyl)-10-propanoyldocetaxel

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; hydrogen fluoride / acetonitrile

2: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran

4: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

5: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; 1H-imidazole; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007