1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide

Base Information

• Chemical Name: 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide
• CAS No.: 1029075-55-5
• Molecular Formula: C₁₅H₁₆N₈O₃S
• Molecular Weight: 388.41
• Mol file: 1029075-55-5.mol

Synonyms:1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide

Chemical Property of 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide

There total 3 articles about 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C8H11N7O3 (1029075-53-3) + phenyl isothiocyanate (103-72-0) → 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide (1029075-55-5)

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1007/s00706-007-0649-7

Reference yield:

1-carbethoxymethyl-4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione (32600-59-2) → 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide (1029075-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / hydrazine hydrate / ethanol / 3 h / Heating

2: 92 percent / ethanol / 1 h / Heating

With hydrazine hydrate; In ethanol;

DOI:10.1007/s00706-007-0649-7

Reference yield:

6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (61541-41-1) → 1-[4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione]acetyl 4-phenyl thiosemicarbazide (1029075-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / K₂CO₃ / dimethylformamide / 2 h / Heating

2: 89 percent / hydrazine hydrate / ethanol / 3 h / Heating

3: 92 percent / ethanol / 1 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s00706-007-0649-7

upstream raw materials:

C₈H₁₁N₇O₃

phenyl isothiocyanate

1-carbethoxymethyl-4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-(4H,6H)-dione

6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

1-[(5-mercapto-4-phenyl-1,2,4-triazol-3-yl)methyl]-4,6-dimethyl-1H-[1,2,3]triazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione

C₁₇H₁₈N₁₀O₃S

C₁₉H₂₀N₈O₄S