(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Base Information

Chemical Name:(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate
CAS No.:322468-31-5
Molecular Formula:C₂₆H₃₆BrO₇P
Molecular Weight:571.445
Hs Code.:

Synonyms:(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

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Chemical Property of (3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Chemical Property:

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Technology Process of (3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

There total 11 articles about (3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17618-04-1
2,5-di-O-benzyl-D-mannitol

: 322468-31-5
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 10 steps

1: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

3: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

4: imidazole / dimethylformamide / 20 °C

5: pyridinium chloride; EtOH / 2 h / Heating

6: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

7: tetrahydrofuran / 2 h / -78 - 20 °C

8: 30 percent aq.H₂O₂ / CH₂Cl₂ / 2 h

9: 90 percent / TBAF / tetrahydrofuran / 1 h

10: DCC; DMAP / CH₂Cl₂ / 2 h

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; ethanol; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 114978-02-8
2,5-di-O-benzyl-1,3(R):4,6(R)-di-O-benzylidene-D-mannitol

: 322468-31-5
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / aq. HCl / ethanol / 4 h / Heating

2: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

3: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

4: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

5: imidazole / dimethylformamide / 20 °C

6: pyridinium chloride; EtOH / 2 h / Heating

7: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

8: tetrahydrofuran / 2 h / -78 - 20 °C

9: 30 percent aq.H₂O₂ / CH₂Cl₂ / 2 h

10: 90 percent / TBAF / tetrahydrofuran / 1 h

11: DCC; DMAP / CH₂Cl₂ / 2 h

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; ethanol; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 114935-28-3
(R)-2-benzyloxy-3-tert-butyldiphenylsilanyloxy-propan-1-ol

: 322468-31-5
(3-O-[2-(4-isobutlyphenyl propanoyl)]-(S)-2-O-benzylglyceryl)-2-bromoethyl-methyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

2: tetrahydrofuran / 2 h / -78 - 20 °C

3: 30 percent aq.H₂O₂ / CH₂Cl₂ / 2 h

4: 90 percent / TBAF / tetrahydrofuran / 1 h

5: DCC; DMAP / CH₂Cl₂ / 2 h

With dmap; tetrabutyl ammonium fluoride; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0009-3084(00)00167-5