1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin

Base Information

• Chemical Name: 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin
• CAS No.: 102222-59-3
• Molecular Formula: C₂₀H₂₄O₅
• Molecular Weight: 344.408
• Mol file: 102222-59-3.mol

Synonyms:1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin

Chemical Property of 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin

There total 5 articles about 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-trimethoxybenzene (634-36-6) → 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin (102222-59-3)

Guidance literature:

Multi-step reaction with 5 steps

1: stannic chloride / CH₂Cl₂

2: 8percent alcoholic alkali / 3 h / Heating

3: 86 percent / Zn amalgam, ccHCl, dimethyl sulphate / toluene; H₂O / 48 h / Heating

4: 94 percent / polyphosphoric acid / 90 °C

5: 1) Mg / 1) THF, 1 h.; 2) THF, room temp., 4 h; 40 degC, 1.5 h.

With hydrogenchloride; PPA; tin(IV) chloride; magnesium; dimethyl sulfate; mercury; zinc; In dichloromethane; water; toluene;

DOI:10.1016/S0040-4020(01)96619-0

Reference yield:

4-oxo-4-(2,3,4-trimethoxyphenyl)butanoic acid (63213-41-2) → 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin (102222-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / Zn amalgam, ccHCl, dimethyl sulphate / toluene; H₂O / 48 h / Heating

2: 94 percent / polyphosphoric acid / 90 °C

3: 1) Mg / 1) THF, 1 h.; 2) THF, room temp., 4 h; 40 degC, 1.5 h.

With hydrogenchloride; PPA; magnesium; dimethyl sulfate; mercury; zinc; In water; toluene;

DOI:10.1016/S0040-4020(01)96619-0

Reference yield:

ethyl 4-oxo-4-(2,3,4-trimethoxyphenyl)butanoate (102222-55-9) → 1-hydroxy-1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin (102222-59-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 8percent alcoholic alkali / 3 h / Heating

2: 86 percent / Zn amalgam, ccHCl, dimethyl sulphate / toluene; H₂O / 48 h / Heating

3: 94 percent / polyphosphoric acid / 90 °C

4: 1) Mg / 1) THF, 1 h.; 2) THF, room temp., 4 h; 40 degC, 1.5 h.

With hydrogenchloride; PPA; magnesium; dimethyl sulfate; mercury; zinc; In water; toluene;

DOI:10.1016/S0040-4020(01)96619-0

upstream raw materials:

1-bromo-4-methoxy-benzene

5,6,7-trimethoxy-3,4-dihydronaphthalen-1(2H)-one

1,2,3-trimethoxybenzene

4-(2,3,4-trimethoxy-phenyl)-butyric acid

Downstream raw materials:

1-(4-methoxyphenyl)-5,6,7-trimethoxytetralin