tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

Base Information

Chemical Name:tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)
CAS No.:1417889-97-4
Molecular Formula:C₆₈H₁₁₀N₈O₁₇S
Molecular Weight:1343.73
Hs Code.:

tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

Synonyms:tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

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Chemical Property of tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

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Technology Process of tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

There total 7 articles about tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 6-(4-sulfamoylphenoxy)hexylammonium trifluoroacetate

: 1417889-98-5
di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate

: 1417889-97-4
tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

Guidance literature:: 6-(4-sulfamoylphenoxy)hexylammonium trifluoroacetate; di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate; With acetic acid; In 1,2-dichloro-ethane; at 75 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm3015348

Reference yield:

: 1417889-98-5
di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate

: 1446011-70-6
4-((6-aminohexyl)oxy)benzenesulfonamide

: 1417889-97-4
tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

Guidance literature:: di-tert-butyl 4-(3-(tert-butoxy)-3-oxopropyl)-4-(2-(2-formyl-1H-imidazol-1-yl)acetamido)heptanedioate; 4-((6-aminohexyl)oxy)benzenesulfonamide; With acetic acid; In 1,2-dichloro-ethane; at 75 ℃; for 0.5h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 142356-33-0
tert-butyl 6-bromohexylcarbamate

: 1417889-97-4
tetra-tert-butyl 4,4′-((2,2′-(2,2′-(((6-(4-sulfamoylphenoxy)hexyl)-azanediyl)bis(methylene))bis(1H-imidazole-2,1-diyl))bis(acetyl))bis-(azanediyl))bis(4-(3-(tert-butoxy)-3-oxopropyl)heptanedioate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 75 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 75 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With potassium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;