1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

Base Information

Chemical Name:1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole
CAS No.:1325212-19-8
Molecular Formula:C₂₂H₂₂BrClN₂O₃S
Molecular Weight:509.851
Hs Code.:

Synonyms:1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

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Chemical Property of 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

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Technology Process of 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

There total 3 articles about 1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1325212-72-3
C₁₆H₁₉ClN₂O

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 1325212-19-8
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

Guidance literature:: C₁₆H₁₉ClN₂O; With sodium hydride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 0.5h; Inert atmosphere;

o-bromobenzenesulfonyl chloride; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 20198-77-0
3,4-dichloro-1-ethyl-pyrrole-2,5-dione

: 1325212-19-8
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; methyl iodide / tetrahydrofuran / 1 h / 25 - 30 °C / Inert atmosphere

1.2: 3 h / 70 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

3.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; magnesium; methyl iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106

Reference yield:

: 1325212-57-4
C₁₆H₁₅ClN₂O₃

: 1325212-19-8
1-(2-bromobenzenesulfonyl)-3-(4-chloro-1-ethyl-2,5-dihydro-1H-pyrrol-3-yl)-5-ethoxy-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 25 - 30 °C / Inert atmosphere

2.2: 3 h / 25 - 30 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.106