[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone

Base Information

• Chemical Name: [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone
• CAS No.: 1586025-54-8
• Molecular Formula: C₂₈H₂₆O₃SSi
• Molecular Weight: 470.664

Synonyms:[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone

Chemical Property of [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone

Chemical Property:

Purity/Quality:

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Technology Process of [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone

There total 3 articles about [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(4-iodophenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone (166975-67-3) + trimethylsilylacetylene (1066-54-2) → [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone (1586025-54-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1002/cmdc.201300270

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone (1586025-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1: |Friedel-Crafts Acylation;

DOI:10.1002/cmdc.201300270

Reference yield:

4-iodobenzoic acid chloride (1711-02-0) → [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][4-[(trimethylsilyl)ethynyl]phenyl]methanone (1586025-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1: |Friedel-Crafts Acylation;

DOI:10.1002/cmdc.201300270

upstream raw materials:

(4-iodophenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone

trimethylsilylacetylene

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

4-iodobenzoic acid chloride

Downstream raw materials:

N-hydroxy-5-(4-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)phenyl)-1H-1,2,3-triazol-1-yl)pentanamide

N-hydroxy-6-(4-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)phenyl)-1H-1,2,3-triazol-1-yl)hexanamide

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