(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

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Chemical Name:(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone
CAS No.:945531-26-0
Molecular Formula:C₃₀H₂₅FN₂O₉
Molecular Weight:576.535
Hs Code.:

Synonyms:(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

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Chemical Property of (4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

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Technology Process of (4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

There total 6 articles about (4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 945531-25-9
(4S,5R)-3-[(R,S)-4-methoxy-3-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-carbonyl]-4-methyl-5-phenyloxazolidin-2-one

: 15017-52-4
4-(bromomethyl)-1-fluoro-2-nitrobenzene

: 945531-26-0
(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

: (4S,5R)-3-[(S)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2007.03.022

Reference yield:

: 945531-23-7
(4S,5R)-(-)-3-acryloyl-4-methyl-5-phenyl-2-oxazolidinone

: 945531-26-0
(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: ozone / ethyl acetate / -78 °C

1.2: dimethyl sulfide / ethyl acetate / -78 - 20 °C

2.1: 59 percent / triethylamine / ethyl acetate / 2 h / 20 °C

3.1: diethyl ether; acetone / 1 h

4.1: 44 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / 20 °C

With ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; ethyl acetate; acetone; acetonitrile;
DOI:10.1016/j.tet.2007.03.022

Reference yield:

: methyl (Z)-2-hydroxy-3-(4-methoxyphenyl)acrylate

: 945531-26-0
(4S,5R)-3-[(R)-2-(4-fluoro-3-nitrobenzyl)-4-methoxy-3-(4-methoxyphenyl)-5-oxotetrahydrofuran-2-carbonyl]-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / triethylamine / ethyl acetate / 2 h / 20 °C

2: diethyl ether; acetone / 1 h

3: 44 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 3 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In diethyl ether; ethyl acetate; acetone; acetonitrile;
DOI:10.1016/j.tet.2007.03.022