(R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Base Information

Chemical Name:(R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
CAS No.:329926-82-1
Molecular Formula:C₁₁H₁₀F₄INO₂
Molecular Weight:391.104
Hs Code.:

Synonyms:(R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

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Technology Process of (R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

There total 2 articles about (R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 329927-16-4
2-fluoro-3-methyl-4-aminophenyl iodide

: 374-35-6,24435-45-8,114715-77-4,44864-47-3
(R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

: 329926-82-1
(R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 4h;

2-fluoro-3-methyl-4-aminophenyl iodide; With 2,6-di-tert-butyl-pyridine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 443-86-7
3-fluoro-2-methylaniline

: 329926-82-1
(R)-N-(2-methyl-3-fluoro-4-iodophenyl)-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Iodine monochloride / acetic acid / 2 h / 70 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C

2.2: 72 h / 20 °C

With oxalyl dichloride; Iodine monochloride; N,N-dimethyl-formamide; In dichloromethane; acetic acid;