<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

Base Information

Chemical Name:<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol
CAS No.:160238-53-9
Molecular Formula:C₂₃H₃₆O₅
Molecular Weight:392.536
Hs Code.:

Synonyms:<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

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Chemical Property of <2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

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Technology Process of <2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

There total 2 articles about <2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (2R,8S,9R,10R)-2-((R)-2,2-Diethyl-[1,3]dioxolan-4-yl)-11-(4-methoxy-benzyloxy)-8,10-dimethyl-9-triethylsilanyloxy-undecan-5-one

: 160238-53-9
<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

Guidance literature:: With camphor-10-sulfonic acid; In methanol; for 20h; Ambient temperature;
DOI:10.1016/0040-4020(96)00811-3

Reference yield:

: 160238-51-7
(2R,3R,9S,10R,11R)-1,2-(diethylmethylenedioxy)-12-(4-methoxybenzyl)oxy-3,9,11-trimethyl-10-(triethylsilyl)oxy-7-dodecen-6-one

: 160238-53-9
<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

Guidance literature:: With Raney Ni(W₂); camphor-10-sulfonic acid; hydrogen; ethyl acetate; Yield given. Multistep reaction; 2.) MeOH, room temperature;
DOI:10.1016/S0040-4039(00)73135-2

Reference yield:

: 160238-53-9
<2R,3R,6R,8R,8(1R),9S>-<3,9-dimethyl-8-<<1-methyl-2-(4-methoxybenzyl)oxy>ethyl>-1,7-dioxaspiro<5.5>undecan-2-yl>methanol

: Acetic acid (S)-2-benzenesulfonyl-1-{(2R,3R,6R,8R,9S)-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-3-(2-methyl-[1,3]dithian-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, from -78 to 0 deg C, 1 h

2: 1.) n-BuLi, HMPA / 1.) THF, hexane, from -78 to 0 deg C, 30 min, 2.) THF, hexane, from -78 to O, 65 min

3: 4-dimethylaminopyridine, pyridine / CH₂Cl₂ / 14 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/0040-4020(96)00811-3