1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:1055042-33-5
Molecular Formula:C₃₀H₃₁N₃O₇S
Molecular Weight:577.658
Hs Code.:

Synonyms:1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 5 articles about 1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202260-08-0
1-[(2R,3S,4S,5R)-3-Azido-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 1055042-33-5
1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 4h; under 1551.4 Torr;
DOI:10.1021/jo9705576

Reference yield:

: 96253-10-0
1-[2,3-epoxy-5-O-(triphenylmethyl)-β-D-lyxofuranosyl]pyrimidine-2,4(1H,3H)-dione

: 1055042-33-5
1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

2: 70 percent / LiN₃ / dimethylformamide / 3 h / 140 °C

3: 95 percent / NaOH / ethanol; H₂O / 2 h / Ambient temperature

4: 87 percent / magnesium monoperphthalate / methanol / Ambient temperature

5: hydrogen / Pd/C / ethyl acetate / 4 h / 1551.4 Torr

With sodium hydroxide; lithium azide; hydrogen; magnesium monoperoxyphthalate hexahydrate; palladium on activated charcoal; In methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo9705576

Reference yield:

: 202259-89-0
Benzoic acid 2-((2R,3R,3aR,9aR)-6-oxo-2-trityloxymethyl-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ylsulfanyl)-ethyl ester

: 1055042-33-5
1-[(2R,3S,4S,5R)-3-Amino-4-(2-hydroxy-ethanesulfonyl)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / LiN₃ / dimethylformamide / 3 h / 140 °C

2: 95 percent / NaOH / ethanol; H₂O / 2 h / Ambient temperature

3: 87 percent / magnesium monoperphthalate / methanol / Ambient temperature

4: hydrogen / Pd/C / ethyl acetate / 4 h / 1551.4 Torr

With sodium hydroxide; lithium azide; hydrogen; magnesium monoperoxyphthalate hexahydrate; palladium on activated charcoal; In methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo9705576