Technology Process of 5-(3-iodo-4,5-dimethoxybenzyl)-6-methylpyrimidine-2,4-diamine
There total 7 articles about 5-(3-iodo-4,5-dimethoxybenzyl)-6-methylpyrimidine-2,4-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
ethanol;
at 0 - 165 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/cmdc.201200291
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0.83 h / 23 °C / Inert atmosphere
2.1: phosphorus tribromide / diethyl ether / 0.83 h / 0 - 23 °C / Inert atmosphere
3.1: sodium methylate / ethanol / 0.5 h / 50 °C / Inert atmosphere
3.2: 18 h / 78 °C / Inert atmosphere
4.1: sodium methylate / ethanol / 18 h / 0 - 78 °C / Inert atmosphere
4.2: 0.5 h / 0 °C
5.1: trichlorophosphate / 2.3 h / 106 °C / Cooling with ice
6.1: ammonia / ethanol / 16 h / 0 - 165 °C / Inert atmosphere
With
sodium tetrahydroborate; ammonia; sodium methylate; phosphorus tribromide; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1002/cmdc.201200291
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C / Inert atmosphere
2.1: sodium tetrahydroborate / tetrahydrofuran / 0.83 h / 23 °C / Inert atmosphere
3.1: phosphorus tribromide / diethyl ether / 0.83 h / 0 - 23 °C / Inert atmosphere
4.1: sodium methylate / ethanol / 0.5 h / 50 °C / Inert atmosphere
4.2: 18 h / 78 °C / Inert atmosphere
5.1: sodium methylate / ethanol / 18 h / 0 - 78 °C / Inert atmosphere
5.2: 0.5 h / 0 °C
6.1: trichlorophosphate / 2.3 h / 106 °C / Cooling with ice
7.1: ammonia / ethanol / 16 h / 0 - 165 °C / Inert atmosphere
With
sodium tetrahydroborate; ammonia; sodium methylate; phosphorus tribromide; potassium carbonate; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200291
